⚡ Synaptic Transmission Steps
🏭
1. Synthesis
NT Made
➡️
🎒
2. Storage
In Vesicles
➡️
📤
3. Release
Exocytosis
⬇️
🔗
4. Binding
To Receptor
➡️
⚡
5. Action
EPSP/IPSP
➡️
🧹
6. Inactivation
Reuptake
🔋 Resting & Action Potential
😴
Resting
-70 mV
➡️
📈
Threshold
-55 mV
➡️
⚡
Depolarization
Na⁺ In
➡️
🔝
Peak
+50 mV
➡️
📉
Repolarization
K⁺ Out
📊 Neurotransmitter Classification
⬇️
💎
Monoamines
🧬
Amino Acids
🔗
Peptides
🎯
Acetylcholine
⬇️
💜
Catecholamines
DA, NE, Epi
🔮
Indolamine
Serotonin
🌟 Major Neurotransmitters
😊
Dopamine
Reward/Motor
💜
Serotonin
Mood/Sleep
🎯
Acetylcholine
Memory/Muscle
⚡
Norepinephrine
Arousal/Alert
⚡
Glutamate
Excitatory
🛑
GABA
Inhibitory
🔗
Glycine
Inhibitory
💫
Endorphins
Pain Relief
🏭 Catecholamine Synthesis
🍽️
Phenylalanine
From Food
⬇️
🎚️
Tyrosine
Rate-Limiting
⬇️
⬇️
⬇️
⬇️
😊 Dopamine Pathways
🛤️
Nigrostriatal
Motor Control
🎰
Mesolimbic
Reward
🧠
Mesocortical
Cognition
🧪
Tuberoinfundibular
Hormones
💊 Drug Effects at Synapse
✅
Agonists
Enhance NT
🚫
Antagonists
Block NT
♻️
Reuptake Block
Keep NT Active
⚗️
MAO Inhibitors
Stop Breakdown